Consumption of pomegranate decreases plasma lipopolysaccharide-binding protein levels, a marker of metabolic endotoxemia, in patients with newly diagnosed colorectal cancer: a randomized controlled clinical trial

Gut microbiota dysbiosis alters the intestinal barrier function, increases plasma lipopolysaccharide (LPS) levels, which promotes endotoxemia, and contributes to the onset and development of colorectal cancer (CRC). We report here for the first time the reduction of plasma LPS-binding protein (LBP)...

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Published inFood & function Vol. 9; no. 5; pp. 2617 - 2622
Main Authors González-Sarrías, A, Núñez-Sánchez, M. A, Ávila-Gálvez, M. A, Monedero-Saiz, T, Rodríguez-Gil, F. J, Martínez-Díaz, Francisco, Selma, M. V, Espín, J. C
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 23.05.2018
Subjects
Cancer
Clinical trials
Colorectal cancer
Colorectal carcinoma
Dysbacteriosis
Endotoxemia
Intestinal microflora
Intestine
Lipopolysaccharide-binding protein
Lipopolysaccharides
LPS-binding protein
Microbiota
Patients
Proteins
Small intestine
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Summary:Gut microbiota dysbiosis alters the intestinal barrier function, increases plasma lipopolysaccharide (LPS) levels, which promotes endotoxemia, and contributes to the onset and development of colorectal cancer (CRC). We report here for the first time the reduction of plasma LPS-binding protein (LBP) levels, a marker of endotoxemia, after pomegranate consumption in newly diagnosed CRC patients. Consumption of pomegranate decreases, in a time-dependent fashion, metabolic endotoxemia in patients with newly diagnosed colorectal cancer.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
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ISSN:2042-6496
2042-650X
DOI:10.1039/c8fo00264a