Spontaneous Swallowing during All-Night Sleep in Patients with Parkinson Disease in Comparison with Healthy Control Subjects

• Published in: Sleep (New York, N.Y.) Vol. 39; no. 4; pp. 847 - 854
• Main Authors: Uludag, Irem Fatma, Tiftikcioglu, Bedile Irem, Ertekin, Cumhur
• Format: Journal Article
• Language: English
• Published: United States Associated Professional Sleep Societies, LLC 01.04.2016
• Subjects: Aged; Case-Control Studies; Cough - complications; Cough - diagnosis; Deglutition; Deglutition Disorders - complications; Deglutition Disorders - diagnosis; Deglutition Disorders - physiopathology; Electroencephalography; Electromyography; Female; Humans; Male; Middle Aged; Neurological Disorders; Parkinson Disease - complications; Parkinson Disease - physiopathology; Saliva; Sialorrhea - complications; Sialorrhea - diagnosis; Sleep; sleep; Parkinson disease; dysphagia; swallowing; cough
• ISSN: 0161-8105; 1550-9109
• DOI: 10.5665/sleep.5640

Spontaneous saliva swallows (SS) appear especially during sleep. The rate of SS was rarely investigated in all-night sleep in patients with Parkinson disease (PD). Dysphagia is a frequent symptom in PD, but the rate of SS was never studied with an all-night sleep electroencephalogram (EEG). A total of 21 patients with PD and 18 age-matched healthy controls were included in the study. Frequencies of SS and coughing were studied in all-night sleep recordings of patients with PD and controls. During all-night sleep, video-EEG 12-channel recording was used including the electromyography (EMG) of the swallowing muscles, nasal airflow, and recording of vertical laryngeal movement using a pair of EEG electrodes over the thyroid cartilage. The total number of SS was increased while the mean duration of sleep was decreased in PD when compared to controls. Sialorrhea and clinical dysphagia, assessed by proper questionnaires, had no effect in any patient group. The new finding was the so-called salvo type of consecutive SS in one set of swallowing. The amount of coughing was significantly increased just after the salvo SS. In PD, the rate of SS was not sufficient to demonstrate the swallowing disorder, such as oropharyngeal dysphagia, but the salvo type of SS was quite frequent. This is a novel finding and may contribute to the understanding of swallowing problems in patients with dysphagic or nondysphagic PD.