Accumulation and chemical forms of cadmium and its effect on essential metals in rat spleen and pancreas

Cadmium was injected sc into female Wistar rats at a dose of 3.0 mg Cd/kg body weight, 4 times a week for 1, 2, 3, 4, 5, and 6 wk. Concentrations of cadmium in the spleen and pancreas were determined, together with essential metals, by inductively coupled plasma-atomic emission spectrometry. Cadmium...

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Bibliographic Details
Published inJournal of toxicology and environmental health Vol. 11; no. 4-6; p. 727
Main Authors Suzuki, K T, Ohnuki, R, Yaguchi, K, Yamada, Y K
Format Journal Article
LanguageEnglish
Published United States 01.04.1983
Subjects
Animals
Cadmium - metabolism
Cadmium - toxicity
Calcium - analysis
Female
Metallothionein - metabolism
Metals - analysis
Pancreas - analysis
Rats
Rats, Inbred Strains
Spleen - analysis
Zinc - analysis
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Summary:Cadmium was injected sc into female Wistar rats at a dose of 3.0 mg Cd/kg body weight, 4 times a week for 1, 2, 3, 4, 5, and 6 wk. Concentrations of cadmium in the spleen and pancreas were determined, together with essential metals, by inductively coupled plasma-atomic emission spectrometry. Cadmium in both tissues increased even after maximum concentration was attained in the liver. Contents of zinc, calcium, and magnesium in the spleen increased with splenomegaly, while content of iron decreased. Concentrations of calcium, magnesium, and iron decreased in the pancreas, while concentration of zinc showed a transitory increase. Cadmium in the spleen and pancreas supernatants was mostly bound to metallothionein, and metallothionein in the pancreas was highly susceptible to oxidation reaction. The spleen and pancreas were histologically less affected by cadmium loading compared to the liver and kidney, and the pancreas showed only slight alterations after injections for 5 and 6 wk.
ISSN:0098-4108
DOI:10.1080/15287398309530380