GPR55 – a putative “type 3” cannabinoid receptor in inflammation

G protein-coupled receptor 55 (GPR55) shares numerous cannabinoid ligands with CB1 and CB2 receptors despite low homology with those classical cannabinoid receptors. The pharmacology of GPR55 is not yet fully elucidated; however, GPR55 utilizes a different signaling system and downstream cascade ass...

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Bibliographic Details
Published inJournal of basic and clinical physiology and pharmacology Vol. 27; no. 3; pp. 297 - 302
Main Authors Yang, Hyewon, Zhou, Juan, Lehmann, Christian
Format Journal Article
LanguageEnglish
Published Berlin De Gruyter 01.05.2016
Walter de Gruyter GmbH
Subjects
CB2
endocannabinoid system
GPR55
immune modulation
inflammation
sepsis
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Summary:G protein-coupled receptor 55 (GPR55) shares numerous cannabinoid ligands with CB1 and CB2 receptors despite low homology with those classical cannabinoid receptors. The pharmacology of GPR55 is not yet fully elucidated; however, GPR55 utilizes a different signaling system and downstream cascade associated with the receptor. Therefore, GPR55 has emerged as a putative “type 3” cannabinoid receptor, establishing a novel class of cannabinoid receptor. Furthermore, the recent evidence of GPR55-CB1 and GPR55-CB2 heteromerization along with its broad distribution from central nervous system to peripheries suggests the importance of GPR55 in various cellular processes and pathologies and as a potential therapeutic target in inflammation.
ISSN:0792-6855
2191-0286
DOI:10.1515/jbcpp-2015-0080