Flavivirus–host interactions: an expanding network of proviral and antiviral factors

Flaviviruses are zoonotic pathogens transmitted by the bite of infected mosquitos and ticks and represent a constant burden to human health. Here we review recent literature aimed at uncovering how flaviviruses interact with the cells that they infect. A better understanding of these interactions ma...

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Bibliographic Details
Published inCurrent opinion in virology Vol. 52; pp. 71 - 77
Main Authors Schneider, William M, Hoffmann, Hans-Heinrich
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.02.2022
Subjects
Animals
Antiviral Agents - metabolism
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
Flavivirus - genetics
Flavivirus - metabolism
Flavivirus Infections
Host-Pathogen Interactions - genetics
Humans
Proviruses
Virus Replication
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Summary:Flaviviruses are zoonotic pathogens transmitted by the bite of infected mosquitos and ticks and represent a constant burden to human health. Here we review recent literature aimed at uncovering how flaviviruses interact with the cells that they infect. A better understanding of these interactions may ultimately lead to novel therapeutic targets. We highlight several studies that employed low-biased methods to discover new protein–protein, protein–RNA, and genetic interactions, and spotlight recent work characterizing the host protein, TMEM41B, which has been shown to be critical for infection by diverse flaviviruses and coronaviruses.
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ISSN:1879-6257
1879-6265
1879-6265
DOI:10.1016/j.coviro.2021.11.007