Hot Water Eliminates the Bitter Taste of Oral Semaglutide: A Report of Four Cases

Semaglutide is a well-designed drug with a special coating that allows for oral administration to patients with type 2 diabetes mellitus. However, patients taking oral semaglutide complain of its bitter taste. We therefore considered suggesting that patients take oral semaglutide with hot water. Whe...

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Published inInternal Medicine Vol. 63; no. 16; pp. 2297 - 2300
Main Authors Okada, Shuichi, Okada, Junichi, Okada, Kazuya, Yamada, Eijiro, Saito, Tsugumichi, Kikkawa, Koji, Ando, Tetsurou, Ohshima, Kihachi
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society of Internal Medicine 15.08.2024
Japan Science and Technology Agency
Subjects
Bitter taste
bitterness
Diabetes mellitus (non-insulin dependent)
hot water
Oral administration
oral semaglutide
Taste
type 2 diabetes mellitus
Water temperature
type 2 diabetes mellitus
hot water
bitterness
oral semaglutide
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Summary:Semaglutide is a well-designed drug with a special coating that allows for oral administration to patients with type 2 diabetes mellitus. However, patients taking oral semaglutide complain of its bitter taste. We therefore considered suggesting that patients take oral semaglutide with hot water. When the hot water temperature was increased to above 46.0°C but below 52.0°C, no bitter taste was perceived, with the daily mean interstitial glucose level remaining at the target range. Taking oral semaglutide with hot water helps reduce its bitter taste.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ObjectType-Report-3
ObjectType-Case Study-4
ISSN:0918-2918
1349-7235
1349-7235
DOI:10.2169/internalmedicine.2608-23