Standardized Seed Extract of Quisqualis indica (HU-033) Attenuates Testosterone Propionate-Induced Benign Prostatic Hyperplasia via α1-Adrenergic Receptors and Androgen/Estrogen Signaling

• Published in: Preventive nutrition and food science Vol. 24; no. 4; pp. 492 - 497
• Main Authors: Baek, Jong Min, Kim, Hyun Jun, Nam, Min Woo, Park, Hyun Jin, Yeon, Sung Hum, Oh, Myeong Hwan, Yoon, Ji Soo, Kwon, Hyo Jung, Lee, Kyu Pil, Lim, Jong Hwan
• Format: Journal Article
• Language: English
• Published: Korea (South) 한국식품영양과학회 01.12.2019; The Korean Society of Food Science and Nutrition
• Subjects: 식품과학; androgen receptor; α1-adrenergic receptor; estrogen receptor α; HU-033; benign prostate hyperplasia
• ISSN: 2287-1098; 2287-8602
• DOI: 10.3746/pnf.2019.24.4.492

Benign prostatic hyperplasia (BPH) is an age-related disease characterized by prostatic enlargement and is the most common urologic symptoms in elderly men 60 years of age and older. Previously, we documented that 70% ethanol (EtOH) seed extract of (QI) attenuates pathological condition of testosterone propionate (TP)-induced BPH rat model modulation of proliferation and apoptosis of prostate cells. Based on this potential of QI, we produced standardized seed extract of QI (HU-033) in order to prove further mechanisms. In this study, we aimed to suggest further mechanisms underlying the relationship between BPH and HU-033. Through not only cellular and nuclear receptor functional assays, but TP-mediated BPH rat model treated with HU-033, we demonstrated that HU-033 exerted antagonist effect on α1 - and α1 -adrenergic receptors and inhibitory effect on protein expression of androgen receptor and estrogen receptor alpha . Taken together, these results suggest that HU-033 is a novel candidate for the management of BPH.