Effect of high‐intensity interval training on hippocampal metabolism in older adolescents

• Published in: Psychophysiology Vol. 59; no. 11; pp. e14090 - n/a
• Main Authors: Valkenborghs, Sarah Ruth, Hillman, Charles H., Al‐Iedani, Oun, Nilsson, Michael, Smith, Jordan J., Leahy, Angus Aaron, Harries, Simon K., Ramadan, Saadallah, Lubans, David Revalds
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.11.2022; John Wiley and Sons Inc
• Subjects: Adolescent; Adolescents; Aged; Cardiorespiratory fitness; cognition; exercise; Female; Glutamates - metabolism; Glutamine; Glutamine - metabolism; High-Intensity Interval Training; Hippocampus; Humans; Interval training; Magnetic resonance spectroscopy; Magnetic Resonance Spectroscopy - methods; Male; Metabolism; Original; Physical activity; Physical fitness; Short term memory; Teenagers; working memory; exercise; cognition; adolescents; working memory
• ISSN: 0048-5772; 1469-8986; 1540-5958
• DOI: 10.1111/psyp.14090

Although well‐evidenced in older adults, the effects of exercise on the hippocampus in youth are relatively unknown. This study examined the impact of a 6‐month school‐based physical activity intervention on hippocampal metabolism in adolescents using magnetic resonance spectroscopy. A subset of lower fit older adolescents [N = 56, 61% female, 16.1 ± 0.4 years] was included from four secondary schools (10 classes) in New South Wales, Australia, who were participating in a larger cluster randomized controlled trial. Participants were randomized to the Burn 2 Learn (B2L) intervention (five classes, 30 participants) or a control group (five classes, 26 participants). Changes in hippocampal metabolism were assessed using linear mixed models adjusted for clustering at the class level. We observed group‐by‐time effects for the B2L intervention on N‐acetylaspartate (NAA) (+2.66 mmol/L, 95% CI 0.20 to 5.11, d = 0.66) and glutamate+glutamine (Glx) (+3.38 mmol/L, 95% CI 0.34 to 6.42, d = 0.67) in the left hippocampus. Increases in left hippocampal NAA and Glx concentrations were associated with improvements in cardiorespiratory fitness (NAA: rs = 0.52, p = .016; Glx: rs = 0.57, p = .007), lower body muscular fitness (NAA: rs = 0.49, p = .018; Glx: rs = 0.59, p = .003), and working memory (NAA: rs = 0.42, p = .032; Glx: rs = 0.43, p = .028) in the intervention group. Our findings suggest physical activity may improve hippocampal metabolism in lower fit older adolescents with implications for working memory. Further studies involving larger samples are needed to replicate our findings. Participation in physical activity has small positive effects on measures of brain and cognition in youth, but the mechanisms are not well understood. This is the first study to examine the effects of an exercise intervention on adolescents' hippocampal metabolism using magnetic resonance spectroscopy and provides evidence for potential mechanisms linking participation in physical activity with enhanced executive function.