Glucagon in the metabolic and nutritional management after total pancreatectomy--a case report

• Published in: Japanese journal of surgery Vol. 19; no. 5; p. 586
• Main Authors: Hirota, M, Ikei, S, Mishima, M, Mori, K, Sakamoto, K, Yamane, T, Idegami, K, Katafuchi, S, Kiyohara, H, Nakashima, Y
• Format: Journal Article
• Language: English
• Published: Japan 01.09.1989
• Subjects: Amino Acids - blood; Blood Glucose - metabolism; Combined Modality Therapy; Diabetes Mellitus, Type 1 - therapy; Glucagon - administration & dosage; Humans; Insulin - administration & dosage; Male; Middle Aged; Pancreatectomy; Pancreatic Neoplasms - radiotherapy; Pancreatic Neoplasms - surgery; Postoperative Complications - blood; Postoperative Complications - therapy
• ISSN: 0047-1909
• DOI: 10.1007/bf02471668

The effects of exogenous glucagon on a totally pancreatectomized patient were evaluated in both the acute postoperative and convalescent periods. In the acute postoperative phase, glucagon stabilized the blood glucose level and allowed the administration of an adequate amount of energy, while during the convalescent period, it proved useful in promoting the metabolism of lipids and amino acids and maintaining liver function. Moreover, we developed a glucagon aerosol which enabled frequent administration without causing major discomfort to the patient and raised the blood glucagon to satisfactory level.