Comprehensive Validation of Cardiovascular Magnetic Resonance Techniques for the Assessment of Myocardial Extracellular Volume

• Published in: Circulation. Cardiovascular imaging Vol. 6; no. 3; pp. 373 - 383
• Main Authors: Miller, Christopher A., Naish, Josephine H., Bishop, Paul, Coutts, Glyn, Clark, David, Zhao, Sha, Ray, Simon G., Yonan, Nizar, Williams, Simon G., Flett, Andrew S., Moon, James C., Greiser, Andreas, Parker, Geoffrey J.M., Schmitt, Matthias
• Format: Journal Article
• Language: English
• Published: United States 01.05.2013
• Subjects: Adult; Aged; Analysis of Variance; Azo Compounds; Biomarkers - metabolism; Collagen - metabolism; Coloring Agents; Contrast Media; Extracellular Matrix - metabolism; Extracellular Matrix - pathology; Female; Fibrosis; Gadolinium DTPA; Heart Diseases - blood; Heart Diseases - diagnosis; Heart Diseases - metabolism; Heart Diseases - pathology; Heart Diseases - surgery; Heart Transplantation; Hematocrit; Humans; Linear Models; Magnetic Resonance Imaging; Male; Middle Aged; Myocardium - metabolism; Myocardium - pathology; Observer Variation; Predictive Value of Tests; Reproducibility of Results; Staining and Labeling - methods; Ventricular Remodeling; Young Adult; collagen; histopathology; MRI; myocardial fibrosis

Extracellular matrix expansion is a key element of ventricular remodeling and a potential therapeutic target. Cardiovascular magnetic resonance (CMR) T1-mapping techniques are increasingly used to evaluate myocardial extracellular volume (ECV); however, the most widely applied methods are without hi...