Two new triterpenoid acids from Kadsura coccinea

• Published in: Archives of pharmacal research Vol. 33; no. 12; pp. 1933 - 1936
• Main Authors: Song, Yan, Zhao, Qing-Jie, Jin, Yong-Sheng, Feng, Chuan-Wei, Chen, Hai-Sheng
• Format: Journal Article
• Language: English
• Published: Heidelberg Pharmaceutical Society of Korea 01.12.2010; 대한약학회
• Subjects: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Cell Line, Tumor; Cell Proliferation - drug effects; HCT116 Cells; Hep G2 Cells; HL-60 Cells; Humans; Kadsura; Magnetic Resonance Spectroscopy; Medicine; Pharmacology/Toxicology; Pharmacy; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Roots; Triterpenes - chemistry; Triterpenes - isolation & purification; Triterpenes - pharmacology; 약학; Coccinic acid; Triterpenoid; Neokadsuranic acid A
• ISSN: 0253-6269; 1976-3786
• DOI: 10.1007/s12272-010-1207-0

An investigation of EtOAc extracts of Kadsura coccinea (Lem.) A. C. Smith, has led to the isolation of two new compounds characterized as 3-hydroxy-12-hydroxyl coccinic acid ( 1 ) and 3-hydroxy-neokadsuranic acid A ( 2 ). Their structures were established by 1D and 2D NMR techniques and mass spectroscopy. Antiproliferative effects of the isolated compounds were evaluated against four human tumor cell lines (A549, HCT116, HL-60 and HepG2), and it was found that compound 1 exhibited antiproliferative effects with IC 50 values ranging from 3.01 to 18.08 μg/mL.