Effect of glucoglycyrrhizin on IgE-mediated immediate hypersensitivity in mice

To evaluate the pharmacological property of glucoglycyrrhizin (GGL), a unique glycoside of glycyrrhetinic acid (GA), we investigated the anti-allergic effect of GGL on IgE-mediated immediate hypersensitivity in mice. GGL exhibited the antiallergic effect against IgE-mediated immediate hypersensitivi...

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Bibliographic Details
Published inJournal of natural medicines Vol. 75; no. 4; pp. 994 - 997
Main Authors Nose, Mitsuhiko, Hisaka, Shinsuke, Tsuge, Atsushi, Hayashi, Hiroaki
Format Journal Article
LanguageEnglish
Published Singapore Springer Singapore 01.09.2021
Springer Nature B.V
Subjects
Allergies
Biological products
Biomedical and Life Sciences
Biomedicine
Complementary & Alternative Medicine
Glycyrrhizin
Hypersensitivity (immediate)
Immunoglobulin E
Immunoglobulins
Medicinal Chemistry
Monoclonal antibodies
Pharmacology/Toxicology
Pharmacy
Plant Sciences
Rodents
Anti-glycyrrhetinic acid monoclonal antibody (6D6)
Glycyrrhizin (GL)
Passive cutaneous anaphylaxis
Glycyrrhetinic acid (GA)
Glucoglycyrrhizin (GGL)
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Summary:To evaluate the pharmacological property of glucoglycyrrhizin (GGL), a unique glycoside of glycyrrhetinic acid (GA), we investigated the anti-allergic effect of GGL on IgE-mediated immediate hypersensitivity in mice. GGL exhibited the antiallergic effect against IgE-mediated immediate hypersensitivity. At a dose of 100 mg/kg, GGL exhibited antiallergic activity equivalent to that of glycyrrhizin (GL). Furthermore, the pretreatment with anti-GA monoclonal antibody eliminated the antiallergic action of GGL. These results indicated that GGL may act in the same way as GL in the human body. Its safety should be verified for its use as a drug similar to GL.
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ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-021-01523-z