Co-Stimulation and Plaque-Antigen-Specific T-Cell Responses in Atherosclerosis

Atherosclerosis is a chronic inflammatory disease of the arterial wall, and T-cell-mediated immune responses to plaque antigens are a prominent component of the inflammatory process. In addition to antigen stimulation, T-cell responses require co-stimulatory signals, the best defined of which are de...

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Bibliographic Details
Published inTrends in cardiovascular medicine Vol. 14; no. 4; pp. 166 - 172
Main Authors Buono, Chiara, Lichtman, Andrew H
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.2004
Elsevier Limited
Subjects
Antigen-Presenting Cells - physiology
Antigens, CD - physiology
Arteriosclerosis - immunology
Humans
Immune system
Immunology
Lymphocyte Activation
Proteins
T cell receptors
T-Lymphocytes - immunology
Tumor Necrosis Factor Receptor Superfamily, Member 7 - physiology
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Summary:Atherosclerosis is a chronic inflammatory disease of the arterial wall, and T-cell-mediated immune responses to plaque antigens are a prominent component of the inflammatory process. In addition to antigen stimulation, T-cell responses require co-stimulatory signals, the best defined of which are delivered by B7 family molecules on antigen-presenting cells binding to CD28 on T cells. T-cell co-stimulation directly influences the CD40/CD154 immunoregulatory pathway, which is well known to influence atherosclerosis. This review discusses recent progress in understanding the role of B7 family molecules in atherosclerosis, and T-cell co-stimulation as an important link between innate immunity and adaptive immune responses to plaque antigens.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1050-1738
1873-2615
DOI:10.1016/j.tcm.2004.03.001