Co-Stimulation and Plaque-Antigen-Specific T-Cell Responses in Atherosclerosis
Atherosclerosis is a chronic inflammatory disease of the arterial wall, and T-cell-mediated immune responses to plaque antigens are a prominent component of the inflammatory process. In addition to antigen stimulation, T-cell responses require co-stimulatory signals, the best defined of which are de...
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Published in | Trends in cardiovascular medicine Vol. 14; no. 4; pp. 166 - 172 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.05.2004
Elsevier Limited |
Subjects | |
Online Access | Get full text |
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Summary: | Atherosclerosis is a chronic inflammatory disease of the arterial wall, and T-cell-mediated immune responses to plaque antigens are a prominent component of the inflammatory process. In addition to antigen stimulation, T-cell responses require co-stimulatory signals, the best defined of which are delivered by B7 family molecules on antigen-presenting cells binding to CD28 on T cells. T-cell co-stimulation directly influences the CD40/CD154 immunoregulatory pathway, which is well known to influence atherosclerosis. This review discusses recent progress in understanding the role of B7 family molecules in atherosclerosis, and T-cell co-stimulation as an important link between innate immunity and adaptive immune responses to plaque antigens. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 1050-1738 1873-2615 |
DOI: | 10.1016/j.tcm.2004.03.001 |