Hepato-pathological hallmarks for the surveillance of Yellow Fever in South American non-human primates

• Published in: Acta tropica Vol. 231; p. 106468
• Main Authors: Passos, Pedro H.O., Ramos, Daniel G., Romano, Alessandro P., Cavalcante, Karina R.L.J., Miranda, Luisa H.M., Coelho, Janice M.C.O., Barros, Ramona C., Martins Filho, Arnaldo J., Quaresma, Juarez A.S., Macêdo, Isabel L., Wilson, Tais M., Sousa, Davi E.R., de Melo, Cristiano B., Castro, Marcio B.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2022
• Subjects: Arboviruses; Histopathology; Immunohistochemistry; Liver; New world primates; Non-human primates; Pathology; Surveillance; Yellow Fever virus; Immunohistochemistry; New world primates; Pathology; Histopathology; Surveillance; Yellow Fever virus; Liver; Arboviruses; Non-human primates
• ISSN: 0001-706X; 1873-6254
• DOI: 10.1016/j.actatropica.2022.106468

•Surveillance of deaths in NHPs is a key point for the prevention of YF in humans.•Determination of hepatic pathological features are crucial for screening YF in NHPs.•YF-associated hepatic injuries may vary between South American NHPs genera.•Humans and NHPs show marked differences in the set of YF-associated hepatic lesions. The early detection and diagnosis of deaths in free-ranging non-human primates (NHPs) are key points for the surveillance of Yellow Fever (YF) in Brazil. The histopathological identification of infectious diseases remains very useful and reliable in the screening and detection of emerging zoonotic diseases such as YF. We surveyed data records and liver slides stained with hematoxylin and eosin from the Epizootics Surveillance Network to control YF, Ministry of Health of Brazil, to evaluate histopathological hallmarks for the diagnosis of the YF virus infection. We selected natural fatal cases in NHPs from the genera Alouatta spp., Callithrix spp., and Sapajus spp. with a positive immunohistochemical assay for YF in liver samples. Our findings showed the full-spectrum YF-associated hepatic lesions in all NHPs, but some histopathological findings differed in the distribution and intensity between the three genera. In our study, South American NHPs showed significant differences in the YF-associated hepatic histopathological features compared to fatal cases reported in humans. [Display omitted]