Negative symptoms in schizophrenia: correlation with clinical and genetic factors

Explore the possible association between clinical factors and genetic variants of the dopamine pathways and negative symptoms. Negative symptoms were assessed in 206 patients with schizophrenia using the Arabic version of the self-evaluation of negative symptoms scale and the Positive and Negative S...

Full description

Saved in:
Bibliographic Details
Published inPharmacogenomics Vol. 22; no. 7; pp. 389 - 399
Main Authors Hajj, Aline, Hallit, Souheil, Chamoun, Karam, Sacre, Hala, Obeid, Sahar, Haddad, Chadia, Dollfus, Sonia, Khabbaz, Lydia Rabbaa
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.05.2021
Future Medicine
Subjects
Antipsychotic Agents - therapeutic use
Catechol O-Methyltransferase - genetics
Chlorpromazine - therapeutic use
Female
Gene Frequency - genetics
Genotyping Techniques
Humans
Life Sciences
Male
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Middle Aged
pharmacogenetic screening
pharmacogenetics
Polymorphism, Single Nucleotide - genetics
Prospective Studies
Psychiatric Status Rating Scales
Receptors, Opioid, mu - genetics
Santé publique et épidémiologie
schizophrenia
Schizophrenia - drug therapy
Schizophrenia - genetics
Schizophrenic Psychology
symptom evaluation
Treatment Outcome
symptom evaluation
schizophrenia
treatment outcome
pharmacogenetic screening
pharmacogenetics
Online AccessGet full text

Cover

More Information
Summary:Explore the possible association between clinical factors and genetic variants of the dopamine pathways and negative symptoms. Negative symptoms were assessed in 206 patients with schizophrenia using the Arabic version of the self-evaluation of negative symptoms scale and the Positive and Negative Syndrome Scale. Genotyping for , , and genes was performed. Multivariable analysis showed that higher self-evaluation of negative symptoms scale scores were significantly associated with higher age, higher chlorpromazine-equivalent daily dose for typical antipsychotics and in married patients. Higher negative Positive and Negative Syndrome Scale scores were significantly associated with women and having the CT genotype for c.677C>T (β = 4.25; p = 0.008) compared with CC patients. Understanding both clinical/genetic factors could help improve the treatment of patients.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1462-2416
1744-8042
DOI:10.2217/pgs-2020-0171