Effect of Concanavalin A on the Homing of Labeled T Lymphocytes

Abstract Treatment in vitro with concanavalin A was found to alter markedly the distribution of 51Cr-labeled lymph node cells to the lymphoid organs of syngeneic recipient mice. The accumulation of labeled cells in recipient spleens was greatly increased at the expense of cell migration to the lymph...

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Bibliographic Details
Published inThe Journal of immunology (1950) Vol. 111; no. 6; pp. 1902 - 1905
Main Authors Gillette, Ronald W, McKenzie, Gail O, Swanson, Margaret H
Format Journal Article
LanguageEnglish
Published United States Am Assoc Immnol 01.12.1973
Subjects
Animals
Cell Movement - drug effects
Chromium Radioisotopes
Concanavalin A - pharmacology
Lectins - pharmacology
Lymph Nodes - cytology
Mannose - pharmacology
Methylglycosides - pharmacology
Mice
Mice, Inbred BALB C
Spleen - cytology
T-Lymphocytes - immunology
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Summary:Abstract Treatment in vitro with concanavalin A was found to alter markedly the distribution of 51Cr-labeled lymph node cells to the lymphoid organs of syngeneic recipient mice. The accumulation of labeled cells in recipient spleens was greatly increased at the expense of cell migration to the lymph nodes. This effect was abrogated by addition of a competitive inhibitor of concanavalin A. The data suggest that pyranoside groups on lymphocyte membranes are associated with the homing and recirculating properties of thymus derived cells.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.111.6.1902