Clozapine tissue concentrations following an apparent suicidal overdose of Clozaril

Clozapine is a tricyclic dibenzodiazepine derivative that is classified as an "atypical" antipsychotic drug. A 25-year-old male was brought to a hospital emergency room following the ingestion of an estimated 20 100-mg tablets of clozapine. After several hours in the hospital, the patient...

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Bibliographic Details
Published inJournal of analytical toxicology Vol. 16; no. 1; p. 54
Main Authors Meeker, J E, Herrmann, P W, Som, C W, Reynolds, P C
Format Journal Article
LanguageEnglish
Published England 01.01.1992
Subjects
Adult
Chromatography, Gas - methods
Clozapine - analogs & derivatives
Clozapine - pharmacokinetics
Clozapine - poisoning
Drug Overdose - metabolism
Gas Chromatography-Mass Spectrometry
Humans
Male
Suicide
Tissue Distribution
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Summary:Clozapine is a tricyclic dibenzodiazepine derivative that is classified as an "atypical" antipsychotic drug. A 25-year-old male was brought to a hospital emergency room following the ingestion of an estimated 20 100-mg tablets of clozapine. After several hours in the hospital, the patient died. The cause of death was listed as acute clozapine intoxication. It was also noted upon autopsy that the patient had an unusual eosinophilic myocarditis. The toxicological and pathological findings are presented in this report.
ISSN:0146-4760
DOI:10.1093/jat/16.1.54