Quantitative intravoxel analysis of microCT-scanned resorbing ceramic biomaterials – Perspectives for computer-aided biomaterial design

Driving the field of micro computed tomography toward more quantitative, rather than qualitative, approaches, we here present a new evaluation method, which uses the unique linear relationship between gray values and x-ray attenuation coefficients, together with the energy-dependence of the latter,...

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Bibliographic Details
Published inJournal of materials research Vol. 29; no. 23; pp. 2757 - 2772
Main Authors Czenek, Agnes, Blanchard, Romane, Dejaco, Alexander, Sigurjónsson, Ólafur E., Örlygsson, Gissur, Gargiulo, Paolo, Hellmich, Christian
Format Journal Article
LanguageEnglish
Published New York, USA Cambridge University Press 14.12.2014
Springer International Publishing
Springer Nature B.V
Subjects
Aluminum
Analysis
Applied and Technical Physics
Biomaterials
Biomedical materials
Bones
Ceramics
Elasticity
Energy
Ethanol
Inorganic Chemistry
Investigations
Invited Feature Paper
Invited Feature Papers
Materials Engineering
Materials research
Materials Science
Microstructure
Nanotechnology
Scanning electron microscopy
Studies
Tissue engineering
Tomography
X-rays
computed tomography
continuum micromechanics
x-ray physics
tissue engineering scaffold
tricalcium phosphate
bone biomaterials
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Summary:Driving the field of micro computed tomography toward more quantitative, rather than qualitative, approaches, we here present a new evaluation method, which uses the unique linear relationship between gray values and x-ray attenuation coefficients, together with the energy-dependence of the latter, to identify (i) the average x-ray energy used in the CT device, (ii) the x-ray attenuation coefficients, and (iii), via the x-ray attenuation average rule, the intravoxel composition, i.e., the microporosity, which, amongst others, governs the voxel-specific mechanical properties, such as stiffness and strength. The method is realized for six 3D tricalcium phosphate scaffolds, seeded with pre-osteoblastic cells and differentiated for 3, 6, and 8 weeks, respectively. The corresponding voxel-specific microporosities turn out to increase during the culturing period (resulting in reduced elastic properties, as determined from micromechanical considerations), while the overall macroporosity remains constant. The new methods are expected to further foster the development of a rationally based and computer-aided design of biomaterials and tissue engineering scaffolds.
ISSN:0884-2914
2044-5326
DOI:10.1557/jmr.2014.326