Storage stability and skin permeation of vitamin C liposomes improved by pectin coating

• Published in: Colloids and surfaces, B, Biointerfaces Vol. 117; pp. 330 - 337
• Main Authors: Zhou, Wei, Liu, Wei, Zou, Liqiang, Liu, Weilin, Liu, Chengmei, Liang, Ruihong, Chen, Jun
• Format: Journal Article
• Language: English
• Published: Netherlands 01.05.2014
• Subjects: Animals; Ascorbic Acid - pharmacology; Coated Materials, Biocompatible - pharmacology; Drug Stability; Liposomes; Male; Mice, Inbred BALB C; Microscopy, Atomic Force; Particle Size; Pectins - pharmacology; Skin Absorption - drug effects; Spectroscopy, Fourier Transform Infrared; Static Electricity; Pectin; Liposomes; Storage stability; Skin permeation; Vitamin C
• ISSN: 0927-7765; 1873-4367
• DOI: 10.1016/j.colsurfb.2014.02.036

A transdermal drug delivery system was prepared by high methoxyl pectin (HMP) or low methoxyl pectin (LMP) coated vitamin C liposomes. HMP coated vitamin C liposomes (HMP-L) and LMP coated vitamin C liposomes (LMP-L) exhibited an increase in average diameter (from 66.9 nm to 117.3 nm and 129.6 nm, respectively), a decrease in zeta potential (from -2.3 mV to -23.9 mV and -35.5 mV, respectively), and a similar entrapment efficiency (48.3-50.1%). Morphology and FTIR analysis confirmed that pectin was successfully coated on the surface of vitamin C liposomes mainly through the hydrogen bonding interactions. Besides, HMP-L and LMP-L exhibited an obvious improvement in storage stability, with lower aggregation, oxidation of lipid and leakage ratio of vitamin C from liposomes, and LMP-L showed better physicochemical stability than HMP-L. Moreover, skin permeation of vitamin C was improved 1.7-fold for HMP-L and 2.1-fold for LMP-L after 24 h, respectively, compared with vitamin C nanoliposomes. Therefore, this study suggested that pectin coated liposomes, especially the LMP-L, could be a promising transdermal drug delivery system with better storage stability and skin permeation.