Carboxymethyl flavonoids and a monoterpene glucoside from Selaginella moellendorffii

• Published in: Archives of pharmacal research Vol. 34; no. 8; pp. 1283 - 1288
• Main Authors: Wang, Hong-Sheng, Sun, Ling, Wang, Yue-Hu, Shi, Ya-Na, Tang, Gui-Hua, Zhao, Fu-Wei, Niu, Hong-Mei, Long, Chun-Lin, Li, Ling
• Format: Journal Article
• Language: English
• Published: Heidelberg Pharmaceutical Society of Korea 01.08.2011; 대한약학회
• Subjects: Animals; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Flavanones - chemistry; Flavanones - isolation & purification; Flavanones - pharmacology; Flavones - chemistry; Flavones - isolation & purification; Flavones - pharmacology; Flavonoids - chemistry; Flavonoids - isolation & purification; Flavonoids - pharmacology; Glucose - metabolism; Glucosides - chemistry; Glucosides - isolation & purification; Glucosides - pharmacology; Insulin Resistance - physiology; Medicine; Molecular Structure; Monoterpenes - chemistry; Myoblasts - drug effects; Pharmacology/Toxicology; Pharmacy; Phytotherapy; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Rats; Selaginellaceae - chemistry; 약학; Flavonoids; Selaginellaceae; Monoterpene glucoside; Insulin-resistance
• ISSN: 0253-6269; 1976-3786
• DOI: 10.1007/s12272-011-0807-7

A new dihydroflavone, 5-carboxymethyl-7,4′-dihydroxyflavonone ( 1 ), and its glucoside 5-carboxymethyl-7,4′-dihydroxyflavonone-7- O -β- d -glucopyranoside ( 2 ), and one new monoterpene glucoside, (4 Z ,6 E )-2,7-dimethyl-8-hydroxyocta-4,6-dienoic acid 8- O -β- d -glucopyranoside ( 3 ), were isolated from the whole plants of Selaginella moellendorffii . Their structures were determined by spectroscopic methods and chemical transformation. Compound 2 was evaluated for the ability to enhance glucose consumption in normal and insulin-resistant L6 muscle cells induced by high concentrations of insulin and glucose. Glucose consumption in insulin-resistant cells (but not in normal cells) was increased 15.2 ± 3.3% ( p < 0.01) by compound 2 at a concentration of 0.1 μM in the presence of insulin (1 nM).