Myeloid Extracellular Vesicles: New Players in Indirect Lung Injury

The most frequent cause of acute respiratory distress syndrome is infection, whether it be direct (pulmonary) or indirect (extrapulmonary) (ARDS). We have begun to create medications specifically for ARDS patients since the coronavirus disease (COVlD-19) pandemic, but our understanding of the underl...

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Bibliographic Details
Published inAmerican journal of respiratory cell and molecular biology Vol. 68; no. 2; pp. 121 - 123
Main Authors Mahida, Rahul Y, Matthay, Michael A
Format Journal Article
LanguageEnglish
Published United States American Thoracic Society 01.02.2023
Subjects
Acute Lung Injury
Cells
Coronaviruses
Extracellular Vesicles
Humans
Lung diseases
Membrane vesicles
miRNA
Mitochondria
mRNA
Myeloid Cells
Proteins
Respiratory diseases
Respiratory Distress Syndrome
Sepsis
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Summary:The most frequent cause of acute respiratory distress syndrome is infection, whether it be direct (pulmonary) or indirect (extrapulmonary) (ARDS). We have begun to create medications specifically for ARDS patients since the coronavirus disease (COVlD-19) pandemic, but our understanding of the underlying pathogenic pathways is still lacking. Finding the paths from sepsis to ARDS will enable the development of novel therapeutic approaches. Extracellular vesicles (EVs) are membrane-bound anuclear structures that serve as a means of intercellular communication. They enable the passage of biological cargo, such as proteins, mitochondria, microRNA, and mRNA, between different types of cells (1). Both in healthy and sick conditions, cells release EVs.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:1044-1549
1535-4989
DOI:10.1165/rcmb.2022-0380ED