Pathobiology of traumatic spinal cord injury: an overview

Traumatic spinal cord injury (SCI) or traumatic myelopathy is a devastating neurological condition and a heavy burden on the health system. There are inflammatory and structural biomarkers with well-defined profiles, and useful for determining the management and prognosis of this pathology. Laborato...

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Published inEgyptian journal of neurosurgery Vol. 39; no. 1; pp. 27 - 5
Main Authors Florez-Perdomo, William A., Guillermo, Andrés Cardona-Cruz, García-Ballestas, Ezequiel, Castilla-Martínez, Abigail, Ramos-Villegas, Yancarlos, Quintana-Pájaro, Loraine, Janjua, Tariq, Agrawal, Amit, Moscote-Salazar, Luis Rafael
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2024
Springer Nature B.V
SpringerOpen
Subjects
Biomarkers
Cytokines
Medicine
Medicine & Public Health
Neurosurgery
Patients
Proteins
Review
Spinal cord injuries
Spinal cord injury
Spinal trauma
Trauma
Traumatic myelopathy
Biomarkers
Spinal trauma
Spinal cord injury
Traumatic myelopathy
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Summary:Traumatic spinal cord injury (SCI) or traumatic myelopathy is a devastating neurological condition and a heavy burden on the health system. There are inflammatory and structural biomarkers with well-defined profiles, and useful for determining the management and prognosis of this pathology. Laboratory studies have shown some utility in confirming the existence of a spinal cord injury. Little knowledge about the molecular processes that occur after a SCI is evident, and it is well known that its understanding is dispensable to establish therapeutic targets that improve the outcomes for this type of patient. Many studies have explored the role of structural and inflammatory markers and some structural and inflammatory biomarkers. In the present article, we review the ongoing research in the field of spinal injury and possible role of biomarkers in the management of these patients.
ISSN:2520-8225
2520-8225
DOI:10.1186/s41984-024-00282-9