The Essential Role of Soluble Aβ Oligomers in Alzheimer’s Disease

Alzheimer’s disease (AD) is a common neurodegenerative disease characterized by amyloid plaque and neurofibrillary tangles (NFT). With the finding that soluble nonfibrillar Aβ levels actually correlate strongly with the severity of the disease, the initial focus on amyloid plaques shifted to the con...

Full description

Saved in:
Bibliographic Details
Published inMolecular neurobiology Vol. 53; no. 3; pp. 1905 - 1924
Main Authors Wang, Zi-Xuan, Tan, Lan, Liu, Jinyuan, Yu, Jin-Tai
Format Journal Article
LanguageEnglish
Published New York Springer US 01.04.2016
Subjects
Alzheimer Disease - metabolism
Amyloid beta-Peptides - chemistry
Amyloid beta-Peptides - metabolism
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Humans
Models, Biological
Molecular Targeted Therapy
Neurobiology
Neurology
Neurosciences
Protein Multimerization
Solubility
Alzheimer’ disease
Aβ
Soluble Aβ oligomers
Online AccessGet full text

Cover

More Information
Summary:Alzheimer’s disease (AD) is a common neurodegenerative disease characterized by amyloid plaque and neurofibrillary tangles (NFT). With the finding that soluble nonfibrillar Aβ levels actually correlate strongly with the severity of the disease, the initial focus on amyloid plaques shifted to the contemporary concept that AD memory failure is caused by soluble Aβ oligomers. The soluble Aβ are known to be more neurotoxicthan fibrillar Aβ species. In this paper, we summarize the essential role of soluble Aβ oligomers in AD and discuss therapeutic strategies that target soluble Aβ oligomers.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0893-7648
1559-1182
DOI:10.1007/s12035-015-9143-0