Further observations on immunization of sheep against Schistosoma mansoni and S. bovis using irradiation-attenuated schistosomula of homologous and heterologous species

This paper describes further characteristics of the immunization of sheep against schistosomes using live, irradiation schistosomula. Sheep immunized with a non-virulent strain of Schistosoma mattheei were protected against a more virulent strain of the same species for over a year. As there was no...

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Bibliographic Details
Published inParasitology Vol. 78; no. 2; p. 185
Main Authors Bickle, Q D, Taylor, M G, James, E R, Nelson, G S, Hussein, M F, Andrews, B J, Dobinson, A R, Marshall, T F
Format Journal Article
LanguageEnglish
Published England 01.04.1979
Subjects
Animals
Feces - parasitology
Immunization
Schistosoma - immunology
Schistosoma - radiation effects
Schistosoma mansoni - immunology
Schistosoma mansoni - radiation effects
Schistosomiasis - parasitology
Schistosomiasis - prevention & control
Schistosomiasis - veterinary
Sheep
Sheep Diseases - parasitology
Sheep Diseases - prevention & control
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Summary:This paper describes further characteristics of the immunization of sheep against schistosomes using live, irradiation schistosomula. Sheep immunized with a non-virulent strain of Schistosoma mattheei were protected against a more virulent strain of the same species for over a year. As there was no evidence that the irradiated parasites were able to persist this long, it was concluded that the vaccine had induced a sterile resistance. Heterologous vaccination, using irradiated S. mattheei schistosomula to immunize against S. bovis or irradiated S. mansoni schistosomula to immunize against S. mattheei, failed to induce any protection.
ISSN:0031-1820
DOI:10.1017/S0031182000049234