Phenotypic analysis of functionally associated molecules on peripheral blood and synovial fluid monocytes from arthritis patients

Surface expression of 16 different membrane molecules was analyzed in peripheral blood and synovial fluid monocytes from patients with rheumatoid arthritis and reactive arthritis compared to controls. The most significant findings were modulated expression of function-associated FcRI, CR1, CR3, MHC...

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Published inRheumatology international Vol. 12; no. 4; p. 153
Main Authors Gadd, S J, Felzmann, T, Majdic, O, Maurer, D, Petera, P, Chen, W J, Smolen, J, Knapp, W
Format Journal Article
LanguageEnglish
Published Germany 01.09.1992
Subjects
Antibodies, Monoclonal
Antigens, Surface - analysis
Arthritis, Reactive - genetics
Arthritis, Reactive - immunology
Arthritis, Rheumatoid - genetics
Arthritis, Rheumatoid - immunology
Blood Cells - immunology
Humans
Monocytes - immunology
Phenotype
Reference Values
Synovial Fluid - cytology
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Summary:Surface expression of 16 different membrane molecules was analyzed in peripheral blood and synovial fluid monocytes from patients with rheumatoid arthritis and reactive arthritis compared to controls. The most significant findings were modulated expression of function-associated FcRI, CR1, CR3, MHC class II and activation-associated CD31, M5, and M6 molecules in arthritis patients compared to controls. Of these molecules, only upregulated expression of MHC class II has previously been reported in synovial fluid monocytes of patients with rheumatoid arthritis.
ISSN:0172-8172
DOI:10.1007/bf00274935