Malignant cell arrest in thymus and spleen of mice bearing transplanted tumors

The relationship between the local outgrowth of different subcutaneous transplantable tumors (plasmacytoma MOPC-315, mastocytoma P-815; Lewis lung carcinoma-3LL; fibrosarcoma; lymphomas and mammary adenocarcinoma) and tumor cell spread in different organs was evaluated. The presence of tumor cells i...

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Published inThe Journal of immunology (1950) Vol. 126; no. 4; pp. 1241 - 1244
Main Authors Haran-Ghera, N, Krauthgamer, R, Peled, A
Format Journal Article
LanguageEnglish
Published United States Am Assoc Immnol 01.04.1981
Subjects
Animals
Cell Transformation, Neoplastic
Goats
Liver
Lung
Mast-Cell Sarcoma - immunology
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Inbred DBA
Neoplasm Transplantation
Rabbits
Rats
Reticulum - pathology
Spleen
Thymus Gland
Time Factors
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Summary:The relationship between the local outgrowth of different subcutaneous transplantable tumors (plasmacytoma MOPC-315, mastocytoma P-815; Lewis lung carcinoma-3LL; fibrosarcoma; lymphomas and mammary adenocarcinoma) and tumor cell spread in different organs was evaluated. The presence of tumor cells in thymus, spleen, lung, and liver was demonstrated by using both in vivo and in vitro methods. Sequestration of tumor cells derived from the transplanted solid tumor was indicated within 3 to 7 days after tumor graft, shortly before or after early palpable outgrowth of the primary tumor was observed. Tumor cells present in thymus and spleen might affect immune responses of tumor-bearing mice.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.126.4.1241