Eco-friendly synthesis and in vitro antibacterial activities of some novel chalcones

• Published in: Bioorganicheskaia khimiia Vol. 39; no. 3; pp. 312 - 317
• Main Authors: Khan, Salman A., Asiri, Abdullah M., Alamry, Khalid A., El-Daly, Samy A., Zayed, Mohie A. M.
• Format: Journal Article
• Language: English
• Published: Dordrecht SP MAIK Nauka/Interperiodica 01.05.2013
• Subjects: Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Biochemistry; Biomedical and Life Sciences; Biomedicine; Bioorganic Chemistry; Chalcones - chemical synthesis; Chalcones - chemistry; Chalcones - pharmacology; Escherichia coli - drug effects; Escherichia coli - pathogenicity; Humans; Life Sciences; Magnetic Resonance Spectroscopy; Microwaves; Organic Chemistry; Pyrazoles - chemical synthesis; Pyrazoles - chemistry; Pyrazoles - pharmacology; Salmonella typhimurium - drug effects; Salmonella typhimurium - pathogenicity; Staphylococcus aureus - drug effects; Staphylococcus aureus - pathogenicity; Streptococcus pyogenes - drug effects; Streptococcus pyogenes - pathogenicity; chalcones; anti-bacterial activity; chloramphenicol
• ISSN: 1068-1620; 0132-3423; 1608-330X
• DOI: 10.1134/S1068162013030072

Chalcone derivatives have been synthesized by reaction of 1-(2,5-dimethyl-furan-3-yl)-ethanone with corresponding active aldehyde in ethanolic NaOH in microwave oven. The structure of these compounds was established by elemental analysis, IR, 1 H NMR, 13 C NMR, and EI-MS spectral analysis. The anti-bacterial activity of these compounds was first tested in vitro by the disc diffusion assay against two Gram-positive and two Gram-negative bacteria, and then the minimum inhibitory concentration (MIC) was determined with the reference of standard drug chloramphenicol. The results showed that pyrazol containing chalcone (compound 8 ) inhibited both types of bacteria (Gram-positive and Gram-negative) better than chloramphenicol.