Influence of bile salts and lipids on intestinal absorption of griseofulvin in man

• Published in: European journal of clinical pharmacology Vol. 31; no. 3; p. 319
• Main Authors: Palma, R, Vidon, N, Houin, G, Pfeiffer, A, Rongier, M, Barre, J, Bernier, J J
• Format: Journal Article
• Language: English
• Published: Germany 01.01.1986
• Subjects: Adult; Bile Acids and Salts - metabolism; Bile Acids and Salts - physiology; Duodenum - metabolism; Fatty Acids - metabolism; Griseofulvin - metabolism; Humans; Intestinal Absorption - drug effects; Jejunum - metabolism; Kinetics; Lipids - pharmacology; Male
• ISSN: 0031-6970
• DOI: 10.1007/bf00981131

The influence of bile salts and lipids on the intestinal absorption of griseofulvin has been studied in 11 healthy male volunteers by the intestinal perfusion technique. The drug in a nutrient solution (Realmentyl) was perfused into the second part of duodenum at 5 ml/min. Intestinal samples were taken continuously at 1 ml/min, 20 cm (at the angle of Treitz) and 45 cm distal to the perfusion point. To study the effect of lipids on griseofulvin absorption, the drug was perfused with solutions A and B, of which B contained a total lipid and caloric load three times that of A. The influence of bile salts on griseofulvin absorption was examined by perfusing the drug on Day 1 with bile salts and again on the following day after bile salt depletion. Bile salts and a varying quantity of lipid perfusate had no significant influence on the duodeno-jejunal griseofulvin absorption rate per cm of intestine. Lipids, however, may still play a role in griseofulvin absorption along the entire intestine.