Antireceptor Antiserum Causes Specific Inhibition of Reactivity to Rat Histocompatibility Antigens

The antigen receptor of lymphocytes destined to form antibody appears to have the characteristics of the immunoglobulin produced. Antibody directed against the combining region of this immunoglobulin should interact with the combining region of the cell receptor for the antigen. Purified Lewis rat a...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 183; no. 4120; pp. 94 - 96
Main Author McKearn, Thomas J.
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 11.01.1974
Subjects
Animals
Antibodies
Antibodies, Anti-Idiotypic
Antibody Formation
Antigen-Antibody Reactions
Antigens
Antiserum
Binding Sites, Antibody
Calcium
Erythrocytes - immunology
Graft vs Host Reaction
Hemagglutination Tests
Histocompatibility Antigens
Hybridization, Genetic
Immune Sera
Immune Tolerance
Immunization
Immunization, Passive
Immunodiffusion
Immunoglobulins
Isoantibodies
Lymph Nodes - immunology
Precipitins
Rats
Rats, Inbred BN
Reactivity
Receptors
Sheep - immunology
Spleen - immunology
Spleen - transplantation
Spleen cells
Tissue grafting
Transplantation, Homologous
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Summary:The antigen receptor of lymphocytes destined to form antibody appears to have the characteristics of the immunoglobulin produced. Antibody directed against the combining region of this immunoglobulin should interact with the combining region of the cell receptor for the antigen. Purified Lewis rat alloantibody prepared against Brown Norway (BN) rat histocompatibility antigens was used to immunize L × BN F$_{1}$ hybrids. The resultant antiserum has antireceptor activity because (i) it yields precipitin lines in gel diffusion when reacted against the immunizing alloantibody; (ii) it inhibits the hemagglutinin antibody response of Lewis rats to BN histocompatibility antigens; and (iii) it inhibits the local graft-versus-host response of Lewis lymphoid cells against BN antigens. This suggests that antireceptor antibody may inhibit cell-mediated responses as well as antibody responses to histocompatibility antigens and may play a role in the regulation of immune responses to such antigens.
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.183.4120.94