Structure and function of apolipoprotein A-I and high-density lipoprotein

Structural biology and molecular modeling have provided intriguing insights into the atomic details of the lipid-associated structure of the major protein component of HDL, apo A-I. For the first time, an atomic resolution map is available for future studies of the molecular interactions of HDL in s...

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Bibliographic Details
Published inCurrent opinion in lipidology Vol. 11; no. 2; p. 105
Main Authors Segrest, J P, Li, L, Anantharamaiah, G M, Harvey, S C, Liadaki, K N, Zannis, V
Format Journal Article
LanguageEnglish
Published England 01.04.2000
Subjects
Animals
Apolipoprotein A-I - chemistry
Apolipoprotein A-I - physiology
Cholesterol - metabolism
Humans
Lipoproteins - chemistry
Lipoproteins, HDL - chemistry
Lipoproteins, HDL - physiology
Mice
Models, Molecular
Protein Conformation
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Summary:Structural biology and molecular modeling have provided intriguing insights into the atomic details of the lipid-associated structure of the major protein component of HDL, apo A-I. For the first time, an atomic resolution map is available for future studies of the molecular interactions of HDL in such biological processes as ABC1-regulated HDL assembly, LCAT activation, receptor binding, reverse lipid transport and HDL heterogeneity. Within the context of this paradigm, the current review summarizes the state of HDL research.
ISSN:0957-9672
DOI:10.1097/00041433-200004000-00002