Superior vena cava syndrome caused by invasive aspergillosis

A 37-year-old man with blastic crisis of chronic myelogenous leukemia was admitted for chemotherapy. After treatment with an infusion of vincristine, he became leukopenic and febrile. Two episodes of gram-negative septicemia were treated with prolonged courses of antibiotics; however, fever persiste...

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Bibliographic Details
Published inChest Vol. 74; no. 6; p. 671
Main Authors Gartenberg, G, Einstein, K, Jagirdar, J
Format Journal Article
LanguageEnglish
Published United States 01.12.1978
Subjects
Adult
Aspergillosis - complications
Humans
Leukemia, Myeloid - complications
Leukemia, Myeloid - drug therapy
Male
Syndrome
Thrombosis - etiology
Vena Cava, Superior
Vincristine - therapeutic use
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Summary:A 37-year-old man with blastic crisis of chronic myelogenous leukemia was admitted for chemotherapy. After treatment with an infusion of vincristine, he became leukopenic and febrile. Two episodes of gram-negative septicemia were treated with prolonged courses of antibiotics; however, fever persisted, and the patient developed the superior vena cava syndrome. Despite therapy with amphotericin B, the patient died. At autopsy a thrombus of Aspergillus was found completely occluding the superior vena cava.
ISSN:0012-3692
DOI:10.1378/chest.74.6.671