Microwave Assisted Synthesis and Antimicrobial Study of Some Novel 2-Azetidinones Derived from 2-(1-Phenylimino-ethyl)-naphthalen-1-ol

Several substituted 2-azetidinone derivatives 2a-q have been synthesized from halogenohydroxy substituted imines 1a-q under microwave irradiation technique. The reactions were carried out using 2-methoxyethanol as an efficient reaction media to afford high yield of product. The structures of newly s...

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Published inOrbital : The Electronic Journal of Chemistry Vol. 11; no. 3; pp. 178 - 185
Main Authors Zangade, Sainath, Shinde, Avinash, Nalwar, Yogesh, Patil, Pravinkumar
Format Journal Article
LanguageEnglish
Published Universidade Federal de Mato Grosso do Sul 01.04.2019
Subjects
2-azetidinones
antimicrobial activity
halogenohydroxy
microwave irradiation
Schiff bases
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Summary:Several substituted 2-azetidinone derivatives 2a-q have been synthesized from halogenohydroxy substituted imines 1a-q under microwave irradiation technique. The reactions were carried out using 2-methoxyethanol as an efficient reaction media to afford high yield of product. The structures of newly synthesized compounds have been established on the basis of elemental analysis, IR, [sup.1]H NMR, [sup.13]C NMR, GC-MS and elemental data. Further, all newly synthesized compounds were screened for their in vitro antimicrobial activity. The antifungal and antibacterial effects of the tested compounds are due to their molecular structure and substituent present. Keywords: 2-azetidinones; halogenohydroxy; Schiff bases; microwave irradiation; antimicrobial activity
ISSN:1984-6428
1984-6428
DOI:10.17807/orbital.v11i3.1393