Larvicidal activity of lipophilic extract of Hypericum carinatum (Clusiaceae) against Aedes aegypti (Diptera: Culicidae) and benzophenones determination

• Published in: Parasitology research (1987) Vol. 112; no. 6; pp. 2367 - 2371
• Main Authors: da Silva, Flavia Corvello, de Barros, Francisco Maikon Corrêa, Prophiro, Josiane Somariva, da Silva, Onilda Santos, Pereira, Thiago Nunes, de Loreto Bordignon, Sérgio A., Eifler-Lima, Vera Lucia, von Poser, Gilsane Lino
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.06.2013
• Subjects: Aedes - drug effects; Aedes aegypti; Animals; Benzophenones - analysis; Benzophenones - pharmacology; Biological Assay; Biomedical and Life Sciences; Biomedicine; Brazil; Clusiaceae; Culicidae; Dengue virus; Diptera; Hypericum; Hypericum - chemistry; Immunology; Insect Vectors; Insecticides - chemistry; Insecticides - isolation & purification; Insecticides - pharmacology; Larva - drug effects; Medical Microbiology; Microbiology; Original Paper; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Survival Analysis; Brazil; Xanthone; Malathion; West Nile Virus; Polysorbate; Benzophenone
• ISSN: 0932-0113; 1432-1955
• DOI: 10.1007/s00436-013-3401-8

In this study, the larvicidal activity of an enriched fraction of the major lipophilic phenolic compounds from Hypericum carinatum Griseb. (Clusiaceae) was investigated against larvae of Aedes aegypti (Diptera: Culicidae), the main vector of dengue virus in Brazil. The larval mortality rate ranged 37.33 to 72.00 % at concentrations of 66–200 μg/mL. The effect demonstrated to be dose-dependent. The lethal concentration 50 % and confidence interval were 100 and 88–111 μg/mL, respectively. The results could be attributed to the presence of cariphenone A and cariphenone B in concentrations of 1.24 ± 0.04 and 0.56 ± 0.01 %, respectively, determined by high-performance liquid chromatography. Besides, the results reinforce the potential of genus Hypericum as source of alternative insecticides.