Influence of vehicle form on efficiency of prostaglandin E2 gel for cervical ripening

• Published in: European journal of obstetrics & gynecology and reproductive biology Vol. 42; no. 3; pp. 177 - 180
• Main Authors: KRISTJAR SKAJAA, MAMSEN, A, JØRGEN SECHER, N
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier 13.12.1991
• Subjects: Adult; Amnion - surgery; Biological and medical sciences; Cellulose; Cervix Uteri - drug effects; Delivery. Postpartum. Lactation; Dinoprostone - administration & dosage; Dinoprostone - pharmacology; Dinoprostone - therapeutic use; Drug Carriers; Female; Gels; Gynecology. Andrology. Obstetrics; Humans; Labor, Induced; Medical sciences; Obstetrical techniques; Polymers; Pregnancy; Starch; Human; Prostaglandin; Arachidonic acid derivatives; Vehicle(excipient); Prostaglandin E2; Uterine cervix; Local administration; Chemotherapy; Treatment; Formulation; Female genital system; Dosage form; Female; Comparative study
• ISSN: 0301-2115; 1872-7654
• DOI: 10.1016/0028-2243(91)90216-8

A double-blind randomized controlled trial compared the efficiency of prostaglandin E2 (PGE2) gel in two different vehicle forms, one solid and the other more liquid, with respect to inducing labour in women with highly unfavourable cervical states. 43 received 0.5 mg PGE2 in a solid gel (Cerviprost) and 37 received 0.5 mg PGE2 in a more liquid cellulose-gel. After one application 18 (42%) and 9 (24%), respectively, went into labour (OR 2.8; 95% confidence interval: 0.8-6.0). After two applications of the gel 91 and 76%, respectively, were in active labour or had amniotomy performed as the cervical state had improved (OR 2.9; 95% confidence interval: 0.8-10.3). It is concluded that the solid gel was more efficient and safe than the more liquid gel.