Dose-response relationship between amphibole fiber lung burden and mesothelioma

In a mesothelioma case-control study, asbestos and other mineral fibers from lung burden were examined as causal factors. Diagnosis was confirmed by a panel of pathologists. For 66 cases and 66 controls from hospitals in five German towns, lung tissue fiber analysis by transmission electron microsco...

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Published inCancer detection and prevention Vol. 23; no. 3; p. 183
Main Authors Rödelsperger, K, Woitowitz, H J, Brückel, B, Arhelger, R, Pohlabeln, H, Jöckel, K H
Format Journal Article
LanguageEnglish
Published England 01.01.1999
Subjects
Age Factors
Aged
Asbestos, Amphibole - adverse effects
Asbestos, Amphibole - analysis
Asbestos, Serpentine - adverse effects
Asbestos, Serpentine - analysis
Asbestosis - epidemiology
Asbestosis - etiology
Body Burden
Carcinogens - adverse effects
Case-Control Studies
Dose-Response Relationship, Drug
Female
Germany - epidemiology
Humans
Lung Neoplasms - chemically induced
Lung Neoplasms - epidemiology
Male
Mesothelioma - chemically induced
Mesothelioma - epidemiology
Microscopy, Electron, Scanning Transmission
Middle Aged
Mineral Fibers - adverse effects
Mineral Fibers - analysis
Odds Ratio
Sex Factors
Smoking
Germany
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Summary:In a mesothelioma case-control study, asbestos and other mineral fibers from lung burden were examined as causal factors. Diagnosis was confirmed by a panel of pathologists. For 66 cases and 66 controls from hospitals in five German towns, lung tissue fiber analysis by transmission electron microscopy was available. Control patients were treated by a surgical lung resection mostly because of lung cancer. For chrysotile and other mineral fibers a significantly increased odds ratio (OR) was not observed. A clear dose-response relationship was demonstrated for the concentration CA of amphibole fibers longer than 5 microm. Between 0.025 and 2.5 fibers/microg dry weight (f/microg) the relationship can be approximated as OR = CA/(0. 025 f/microg). Similar but less distinct dose-response relationships were found in a Canadian and an Australian study. It is concluded that among German mesothelioma patients factors not associated with amphibole fiber concentration are not predominating.
ISSN:0361-090X
DOI:10.1046/j.1525-1500.1999.99018.x