Metabolic fate of L-[methyl-11C]methionine in human plasma

The metabolites of L-[methyl-11C]methionine in the plasma of 8 patients with tumors were measured for 60 min after injection. In the plasma, after a rapid clearance, the total radioactivity remained constant, and protein-bound radioactivity increased rapidly. Non protein metabolites detected by HPLC...

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Published inEuropean journal of nuclear medicine Vol. 15; no. 10; p. 665
Main Authors Ishiwata, K, Hatazawa, J, Kubota, K, Kameyama, M, Itoh, M, Matsuzawa, T, Takahashi, T, Iwata, R, Ido, T
Format Journal Article
LanguageEnglish
Published Germany 01.10.1989
Subjects
Adolescent
Adult
Aged
Brain Neoplasms - blood
Brain Neoplasms - diagnostic imaging
Carbon Radioisotopes
Humans
Lung Neoplasms - blood
Lung Neoplasms - diagnostic imaging
Methionine - blood
Middle Aged
Tomography, Emission-Computed
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Summary:The metabolites of L-[methyl-11C]methionine in the plasma of 8 patients with tumors were measured for 60 min after injection. In the plasma, after a rapid clearance, the total radioactivity remained constant, and protein-bound radioactivity increased rapidly. Non protein metabolites detected by HPLC as at least two components besides methionine, increased with time. Significant individual variations for the metabolism were observed. At 60 min after injection, 36.5% (range: 16%-72%) and 45.3% (range: 13%-74%) of the 11C was measured as methionine and labeled proteins, respectively.
ISSN:0340-6997
DOI:10.1007/bf00251681