Mononuclear Leukocytes from Mice with Resected Tumor Induce Resistance to Transplantation of Tumor Cells to Animals

• Published in: Bulletin of experimental biology and medicine Vol. 148; no. 1; pp. 86 - 88
• Main Authors: Sitdikova, S. M, Kiselevskii, M. V, Sel'chuk, V. Yu, Amandzholov, B. S, Voyushin, K. E, Luchenko, I. M, Donenko, F. V
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.07.2009; Springer US; Springer Nature B.V
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Carcinoma, Ehrlich Tumor - immunology; Carcinoma, Ehrlich Tumor - pathology; Cell Biology; Ehrlich carcinoma; Internal Medicine; Laboratory Medicine; Leukocytes, Mononuclear - immunology; Male; Melanoma, Experimental - immunology; Melanoma, Experimental - pathology; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; mononuclear leukocytes; Neoplasm Transplantation - immunology; Pathology; S-91 melanoma; S-91 melanoma; Ehrlich carcinoma; mononuclear leukocytes
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-009-0648-2

Experiments on male C57Bl/6 mice with intraperitoneally transplanted Ehrlich carcinoma and DBA/2 mice with subcutaneously transplanted S-91 melanoma showed that preliminary injection of mononuclear leukocytes obtained from animals 6-8 h after tumor resection induce resistance to transplantation of malignant transformed cells. Our results suggest that not only humoral factors, but also immunocompetent cells are involved in the regulation of tumor growth. The resistance to tumor transplantation was not induced by mononuclear leukocytes isolated over the first hours and 10-12 h after removal of the primary tumor node, which excludes the direct cytotoxic effect of these cells and suggests that this phenomenon is not associated with activation of the effector mechanisms for innate and adoptive immunity.