Modulation of human colonic arachidonic acid metabolism by sulfasalazine

The effects of sulfasalazine and its moieties on synthesis of individual products of arachidonic acid metabolism by human colonic mucosa have been investigated. Sulfasalazine inhibited synthesis of the lipoxygenase products. Sulfasalazine and sulfapyridine also inhibited synthesis of thromboxane B2...

Full description

Saved in:
Bibliographic Details
Published inDigestive diseases and sciences Vol. 30; no. 12; p. 1161
Main Authors Hawkey, C J, Boughton-Smith, N K, Whittle, B J
Format Journal Article
LanguageEnglish
Published United States 01.12.1985
Subjects
Aminosalicylic Acids - pharmacology
Arachidonic Acid
Arachidonic Acids - metabolism
Autoradiography
Chromatography, Thin Layer - methods
Colitis, Ulcerative - drug therapy
Colitis, Ulcerative - enzymology
Colon - drug effects
Colon - enzymology
Humans
In Vitro Techniques
Intestinal Mucosa - enzymology
Lipoxygenase - metabolism
Mesalamine
Prostaglandin-Endoperoxide Synthases - metabolism
Prostaglandins - metabolism
Sulfapyridine - pharmacology
Sulfasalazine - pharmacology
Thromboxane B2 - metabolism
Online AccessGet more information

Cover

More Information
Summary:The effects of sulfasalazine and its moieties on synthesis of individual products of arachidonic acid metabolism by human colonic mucosa have been investigated. Sulfasalazine inhibited synthesis of the lipoxygenase products. Sulfasalazine and sulfapyridine also inhibited synthesis of thromboxane B2 while enhancing synthesis of prostaglandin (PG) F2 alpha or PGE2, respectively. Inhibition of synthesis of lipoxygenase products and modulation of the profile of cyclooxygenase products could reduce inflammation and enhance mucosal resistance to damage in ulcerative colitis.
ISSN:0163-2116
DOI:10.1007/bf01314051