Hyalinizing trabecular tumor: Cytologic, histologic and molecular features and diagnostic considerations

• Published in: Annals of diagnostic pathology Vol. 54; p. 151803
• Main Authors: Podany, Peter, Gilani, Syed M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2021
• Subjects: Carcinoma, Neuroendocrine - diagnosis; Carcinoma, Neuroendocrine - pathology; Carcinoma, Papillary - diagnosis; Carcinoma, Papillary - pathology; Cytodiagnosis - methods; Fine needle aspiration; Histology; Humans; Hyalinizing trabecular tumor; Molecular testing; Thyroid; Thyroid Cancer, Papillary - diagnosis; Thyroid Cancer, Papillary - pathology; Thyroid Gland - pathology; Thyroid Neoplasms - diagnosis; Thyroid Neoplasms - pathology; Molecular testing; Hyalinizing trabecular tumor; Histology; Thyroid; Fine needle aspiration
• ISSN: 1092-9134; 1532-8198
• DOI: 10.1016/j.anndiagpath.2021.151803

Hyalinizing trabecular tumors are a follicular origin neoplasm of the thyroid that usually present as an asymptomatic, well circumscribed, solitary mass. However, diagnosis of a hyalinizing trabecular tumor may be challenging especially on fine needle aspiration cytology and requires careful examination of the specimen to rule out potential mimickers such as papillary thyroid carcinoma, medullary thyroid carcinoma, paraganglioma, other follicular patterned neoplasms, intrathyroidal parathyroid tissue, and metastatic disease. We will review the cytologic, histologic and molecular features of hyalinizing trabecular tumors that aid in distinction from these mimickers with overlapping morphologic features and help ensure proper diagnosis for appropriate management. •Hyalinizing trabecular tumor (HTT) is a follicular origin origin tumor with an excellent prognosis.•FNANA cytology features of HTT should be differentiated from other mimickers especially papillary thyroid carcinoma.•Immunohistochemical staining pattern and molecular testing may be helpful to provide additional diagnostic information.