The Mucosal Innate Immune Response in Primary Human Papillomavirus Infection: A Pilot Study

The purpose of the study was to evaluate the mucosal immune response in women affected by primary human papillomavirus (HPV) infection, in comparison with HPV-negative women with no previous history of HPV. A case-control study comparing the activity of myeloperoxidase (MPO) and lactoferrin (LF) bet...

Full description

Saved in:
Bibliographic Details
Published inJournal of lower genital tract disease Vol. 20; no. 4; p. 338
Main Authors Gardella, Barbara, Iacobone, Anna Daniela, Musacchi, Valentina, Calvino, Isabel Giacoma, De Amici, Mara, Torre, Cristina, Bogliolo, Stefano, Spinillo, Arsenio
Format Journal Article
LanguageEnglish
Published United States 01.10.2016
Subjects
Adolescent
Adult
Aged
Apoptosis
Case-Control Studies
Female
Flow Cytometry
Humans
Immunity, Innate
Immunity, Mucosal
Lactoferrin - analysis
Middle Aged
Neutrophils - immunology
Papillomaviridae - immunology
Papillomavirus Infections - immunology
Papillomavirus Infections - pathology
Peroxidase - analysis
Pilot Projects
Young Adult
Online AccessGet more information

Cover

More Information
Summary:The purpose of the study was to evaluate the mucosal immune response in women affected by primary human papillomavirus (HPV) infection, in comparison with HPV-negative women with no previous history of HPV. A case-control study comparing the activity of myeloperoxidase (MPO) and lactoferrin (LF) between 19 HPV-positive and 19 HPV-negative women matched for age. Plasmatic and cervicovaginal levels of polymorphonuclear neutrophils (PMN) exhibiting MPO and LF receptors were measured using cytofluorimetric analysis and expressed as mean of percentages. Cervicovaginal levels of MPO-/LF- PMN were lower among HPV-negative women, with a mean rate of 18.81% (SD, 21.38), as opposed to a mean rate of 35.56% (SD, 21.02) (P = 0.020) in HPV-positive women. A similar significant difference was not proven in plasma. The mean rates of plasmatic levels of MPO-/LF- PMN were 36.21% (SD, 16.87) and 36.93% (SD, 10.54) (P = 0.875) in cases and controls, respectively. All patients were evaluated 1 year later, and only 6 cases became negative. The presence of MPO-/LF- PMN has been considered as a marker of lower rate of apoptosis of HPV-infected cells. This could explain why HPV-positive women are less capable to deal with a primary infection.
ISSN:1526-0976
DOI:10.1097/LGT.0000000000000245