Postmortem tissue digoxin concentrations in infants and children

The concentrations of digoxin in tissues of premature infants, full-term infants and older children obtained at autopsy were determined by a radioimmunoassay procedure. Infants were found to have much higher concentrations in the right and left ventricle (about 190 ng/g) than older children (about 7...

Full description

Saved in:
Bibliographic Details
Published inCirculation (New York, N.Y.) Vol. 52; no. 6; pp. 1128 - 1131
Main Authors Kim, P W, Krasula, R W, Soyka, L F, Hastreiter, A R
Format Journal Article
LanguageEnglish
Published United States 01.12.1975
Subjects
Age Factors
Autopsy
Body Weight
Child
Child, Preschool
Digoxin - administration & dosage
Digoxin - analysis
Digoxin - blood
Heart Failure - drug therapy
Humans
Infant
Infant, Newborn
Infant, Premature
Kidney - analysis
Muscles - analysis
Myocardium - analysis
Online AccessGet full text

Cover

More Information
Summary:The concentrations of digoxin in tissues of premature infants, full-term infants and older children obtained at autopsy were determined by a radioimmunoassay procedure. Infants were found to have much higher concentrations in the right and left ventricle (about 190 ng/g) than older children (about 70 ng/g) and adults as reported in the literature. Renal concentrations were lower in the premature group which may be related to their limited excretory capacity for digoxin. The relatively high myocardial concentrations of digoxin found in this study suggest that the usually recommended doses for infants may be excessive.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.52.6.1128