Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: gradual release enhances activity

We demonstrate an approach to the surface-mediated release of a synthetic N-acylated L-homoserine lactone (AHL) modulator of bacterial quorum sensing (QS). AHL released gradually from thin films of poly(lactide-co-glycolide) (PLG) is shown to activate QS in the model symbiont Vibrio fischeri at leve...

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Published inChemical communications (Cambridge, England) Vol. 47; no. 1; pp. 370 - 372
Main Authors Breitbach, Anthony S, Broderick, Adam H, Jewell, Christopher M, Gunasekaran, Suvai, Lin, Qi, Lynn, David M, Blackwell, Helen E
Format Journal Article
LanguageEnglish
Published England 07.01.2011
Subjects
4-Butyrolactone - analogs & derivatives
4-Butyrolactone - chemical synthesis
4-Butyrolactone - chemistry
4-Butyrolactone - pharmacology
Aliivibrio fischeri - drug effects
Molecular Structure
Molecular Weight
Quorum Sensing - drug effects
Surface Properties
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Summary:We demonstrate an approach to the surface-mediated release of a synthetic N-acylated L-homoserine lactone (AHL) modulator of bacterial quorum sensing (QS). AHL released gradually from thin films of poly(lactide-co-glycolide) (PLG) is shown to activate QS in the model symbiont Vibrio fischeri at levels that exceed those promoted by direct solution-based administration.
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These authors contributed equally to this work.
ISSN:1359-7345
1364-548X
DOI:10.1039/c0cc02316g