Ultra early recurrence in giant congenital malignant rhabdoid tumor of spine

Background Malignant rhabdoid tumor (MRT) is an aggressive tumor of infancy and childhood that rarely presents as a primary spinal or spinal cord tumor. There are only three reported cases of spinal MRT in infants. Objective We present a similar case in a 3-month male child who developed ultra-early...

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Bibliographic Details
Published inChild's nervous system Vol. 32; no. 12; pp. 2471 - 2474
Main Authors Singla, Navneet, Kapoor, Ankur, Chatterjee, Debajyoti, Radotra, B. D.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2016
Subjects
Case Report
Humans
Infant
Male
Medicine
Medicine & Public Health
Neoplasm Recurrence, Local - pathology
Neurosciences
Neurosurgery
Rhabdoid Tumor - congenital
Rhabdoid Tumor - pathology
Spinal Cord Neoplasms - congenital
Spinal Cord Neoplasms - pathology
Rhabdoid tumor
Chromosome 22
Prognosis
Spine
INI1
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Summary:Background Malignant rhabdoid tumor (MRT) is an aggressive tumor of infancy and childhood that rarely presents as a primary spinal or spinal cord tumor. There are only three reported cases of spinal MRT in infants. Objective We present a similar case in a 3-month male child who developed ultra-early recurrence, 4 weeks after complete excision. The diagnosis was confirmed by immunohistochemistry showing inactivation of the INI1 gene. Result Despite surgical excision and adjuvant chemoradiotherapy, these tumors have a progressive course and recurrence is a common phenomenon. Conclusion We believe that MRT must be considered in the differential diagnosis of the intra/paraspinal masses, especially in the infants.
Bibliography:ObjectType-Case Study-2
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ISSN:0256-7040
1433-0350
DOI:10.1007/s00381-016-3178-z