Clinical features and therapeutic management of choroidal osteoma: A systematic review

• Published in: Survey of ophthalmology Vol. 68; no. 6; pp. 1084 - 1092
• Main Authors: Zhang, Li, Ran, Qi-Bo, Lei, Chun-Yan, Zhang, Mei-Xia
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2023
• Subjects: Anti-VEGF agents; Choroid - pathology; Choroid Neoplasms - complications; Choroid Neoplasms - diagnosis; Choroid Neoplasms - therapy; Choroidal neovascularization; Choroidal Neovascularization - drug therapy; Choroidal osteoma; Fluorescein Angiography; Humans; Osteoma - complications; Osteoma - diagnosis; Osteoma - therapy; Retinal Pigment Epithelium - pathology; Subretinal fluid; Systematic review; Tomography, Optical Coherence; Anti-VEGF agents; Systematic review; Choroidal neovascularization; Subretinal fluid; Choroidal osteoma
• ISSN: 0039-6257; 1879-3304
• DOI: 10.1016/j.survophthal.2023.06.002

Choroidal osteoma is a benign ossifying tumor within the choroid. Complications associated with choroidal osteoma, including disruption of retinal pigment epithelium, atrophy of photoreceptors, subretinal fluid, and choroidal neovascularization, present challenges for clinicians, and management remain controversial. We performed a comprehensive search in the PubMed, EMBASE, and Ovid databases for published studies and case reports relating to the management of choroidal osteoma. Since it was first described in 1978, various case reports of ocular complications associated with choroidal osteoma have been documented, and various therapies have yielded different outcomes. We systematically evaluate the literature published on this rare entity.