Association of genetic polymorphisms of IL1β -511 C>T, IL1RN VNTR 86 bp, IL6 -174 G>C, IL10 -819 C>T and TNFα -308 G>A, involved in symptomatic patients with dengue in Brazil

• Published in: Inflammation research Vol. 65; no. 11; pp. 925 - 932
• Main Authors: Cansanção, Isaac Farias, do Carmo, Ana Paula Santos, Leite, Robério Dias, Portela, Rosana Deyse Ponte, de Sá Leitão Paiva Júnior, Sérgio, de Queiroz Balbino, Valdir, Rabenhorst, Silvia Helena Barem
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.11.2016
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Allergology; Biomedical and Life Sciences; Biomedicine; Brazil; Child; Child, Preschool; Cytokines - genetics; Dengue - genetics; Dermatology; Female; Genetic Predisposition to Disease; Genotype; Humans; Immunology; Infant; Interleukin 1 Receptor Antagonist Protein - genetics; Male; Middle Aged; Neurology; Original Research Paper; Pharmacology/Toxicology; Polymorphism, Single Nucleotide; Rheumatology; Young Adult; Interleukin polymorphism; Non-dengue infection; Risk; Dengue
• ISSN: 1023-3830; 1420-908X
• DOI: 10.1007/s00011-016-0975-5

Objective In this study, single nucleotide polymorphisms (SNP) of interleukin (IL) 1β -511 C>T, IL1RN VNTR 86 bp, IL6 -174 G>C, IL10 -819 C>T and TNFα -308 G>A were analyzed by PCR–RFLP with symptoms of dengue with the clinical features. Subjects 196 individuals admitted to the São José Infectious Diseases Hospital with suspected dengue infection. Dengue was confirmed in 111 of the patients. The control group consisted of 85 other individuals confirmed without dengue. Results It was demonstrated that the presence the T allele of IL1β ( P  < 0.05) was associated with susceptibility to developing the disease. Other results also suggested that the polymorphism in the combinations IL6  ×  IL1β (C and T alleles, respectively), IL1β (T allele) ×  IL1RN (*2/*2 genotype), IL6 (C allele) ×  TNFα (A allele), IL10 (C/T genotype) ×  TNFα (A/A genotype) ( P  < 0.01, P  = 0.01, P  < 0.05 and P  = 0.03, respectively) were associated with predisposition to developing the disease and its symptoms. Conclusions In summary, the findings of this study in a Brazilian population point out the importance of studies of combinations of polymorphisms in the development of dengue, which can increase the risk of dengue infection and its severity.