Nucleoside Triphosphate Pyrophosphohydrolase of the Plasma Membrane of the Liver Cell

An activity, named nucleoside triphosphate pyrophosphohydrolase, has been found in plasma membrane preparations from rat liver. The enzyme catalyzes the formation of inorganic pyrophosphate from adenosine triphosphate (but not from adenosine diphosphate) and other nucleoside triphosphates by a react...

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Published inThe Journal of biological chemistry Vol. 242; no. 4; pp. 736 - 739
Main Authors Lieberman, I, Lansing, A I, Lynch, W E
Format Journal Article
LanguageEnglish
Published United States American Society for Biochemistry and Molecular Biology 25.02.1967
Subjects
Adenosine Triphosphate - metabolism
Animals
Cell Membrane - enzymology
Diphosphates - biosynthesis
In Vitro Techniques
Liver - cytology
Liver - enzymology
Pyrophosphatases - metabolism
Rats
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Summary:An activity, named nucleoside triphosphate pyrophosphohydrolase, has been found in plasma membrane preparations from rat liver. The enzyme catalyzes the formation of inorganic pyrophosphate from adenosine triphosphate (but not from adenosine diphosphate) and other nucleoside triphosphates by a reaction that appears to be a simple hydrolysis. Evidence is presented to show that the activity is an authentic component of the membranes and that it is largely or completely absent from the liver microsome fraction.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(18)96266-6