Anhydrous nanoprecipitation for the preparation of nanodispersions of tenofovir disoproxil fumarate in oils as candidate long-acting injectable depot formulations

The facile formation of drug nanoparticles in injectable/ingestible oils, of water-soluble antiretroviral tenofovir disoproxil fumarate, using a novel nanoprecipitation is presented with studies showing drug release into relevant aqueous media. The facile formation of drug nanoparticles in injectabl...

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Bibliographic Details
Published inNanoscale advances Vol. 1; no. 11; pp. 431 - 437
Main Authors Hobson, James J, Curley, Paul, Savage, Alison C, Al-khouja, Amer, Siccardi, Marco, Flexner, Charles, Meyers, Caren Freel, Owen, Andrew, Rannard, Steve P
Format Journal Article
LanguageEnglish
Published RSC 05.11.2019
Subjects
Chemistry
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Summary:The facile formation of drug nanoparticles in injectable/ingestible oils, of water-soluble antiretroviral tenofovir disoproxil fumarate, using a novel nanoprecipitation is presented with studies showing drug release into relevant aqueous media. The facile formation of drug nanoparticles in injectable/ingestible oils, of water-soluble antiretroviral tenofovir disoproxil fumarate, using a novel nanoprecipitation is presented with studies showing drug release into relevant aqueous media.
Bibliography:Electronic supplementary information (ESI) available: Materials and methods; dynamic light scattering, isothermal calorimetry and comparative release data. See DOI
10.1039/c9na00529c
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:2516-0230
2516-0230
DOI:10.1039/c9na00529c