Voltammetry of Diclofenac at Graphite, Carbon Composites, and Molecularly Imprinted Polymer-Composite Electrodes

• Published in: Analytical letters Vol. 37; no. 5; pp. 915 - 927
• Main Authors: Blanco-López, M. Carmen, Fernández-Llano, Laura, Lobo-Castañón, M. Jesús, Miranda-Ordieres, Arturo J., Tuñón-Blanco, Paulino
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Taylor & Francis Group 01.01.2004; Taylor & Francis
• Subjects: Analytical chemistry; Chemistry; Composite electrodes; Diclofenac; Electrochemical methods; Epoxy-graphite; Exact sciences and technology; Molecular imprinting; Drug; Carbon black; Molecular structure; Electrochemical method; Tetrafluoroethylene polymer; Epoxy-graphite; Carbon electrode; Polymer; Voltammetry; Carbon; Diclofenac; Acetonitrile; Graphite; Molecular imprinting; Composite electrodes; Modified material
• ISSN: 0003-2719; 1532-236X
• DOI: 10.1081/AL-120030287

The electrochemical behavior of diclofenac (DCF) at graphite electrodes was investigated. The drug is irreversibly oxidized at 0.84 V (pH 1), giving rise to some products, which exhibit two reversible process with formal potential of 0.39 and 0.63 V. Carbon composite electrodes of different nature [polytetrafluoroethylene-graphite (PTFE-G), epoxy-graphite (EG), epoxy-carbon black (E-CB)] were also investigated for voltammetric detection of DCF. A similar electrochemical behavior was observed on these electrodes although graphite was preferred over carbon black as conducting phase, and both PTFE and epoxy could act as agglomerant. Electrodes constructed with these materials could be modified with molecularly imprinted polymers (MIPs), and allowed detection of DCF after incubation in an acetonitrile solution of the drug.