Childhood Cardiovascular Health, Obesity, and Some Related Disorders: Insights into Chronic Inflammation and Oxidative Stress

• Published in: International journal of molecular sciences Vol. 25; no. 17; p. 9706
• Main Authors: He, Marcun Varda, Natasa
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.09.2024
• Subjects: Body mass index; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - etiology; cardiovascular health; Child; Child Health; chronic inflammation; Cocoa; Complications and side effects; Development and progression; Health aspects; Humans; Inflammation; Inflammation - metabolism; Metabolic Syndrome; Mortality; Obesity; Obesity in children; obesity-related comorbidities; Oxidative Stress; Pediatric Obesity - complications; Pediatric Obesity - epidemiology; Pediatric Obesity - metabolism; Pediatric research; Risk factors; Slovenia; obesity-related comorbidities; cardiovascular health; chronic inflammation; obesity; oxidative stress; child
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25179706

Childhood obesity and associated metabolic abnormalities have become pressing public health concerns worldwide, significantly impacting cardiovascular health. Metabolic syndrome, characterized by a cluster of metabolic abnormalities including central obesity, altered glucose metabolism, dyslipidemia, and arterial hypertension, has emerged as a critical precursor to cardiovascular disease. Chronic systemic inflammation and oxidative stress seem to play pivotal roles in the pathogenesis of childhood obesity-related disorders such as early atherosclerosis. A significant distinction between the objective components of cardiovascular health metrics, including body mass index, blood pressure, cholesterol, and fasting glucose levels, and the definition of metabolic syndrome is evident in the identification of obesity. Whereas cardiovascular health metrics predominantly rely on body mass index percentiles to assess obesity, metabolic syndrome criteria prioritize waist circumference, specifically targeting individuals with a measurement ≥90th percentile. This discrepancy emphasizes the need for a nuanced approach in assessing the risks associated with obesity and underscores the importance of considering multiple factors when evaluating cardiovascular risk in children. By recognizing the complex interplay between various health metrics, obesity and metabolic syndrome criteria, clinicians can more accurately identify individuals at risk and tailor interventions accordingly to mitigate cardiovascular disease in children with obesity.