Immunodominant Mycobacterium tuberculosis Protein Rv1507A Elicits Th1 Response and Modulates Host Macrophage Effector Functions

• Published in: Frontiers in immunology Vol. 11; p. 1199
• Main Authors: Arora, Simran Kaur, Alam, Anwar, Naqvi, Nilofer, Ahmad, Javeed, Sheikh, Javaid Ahmad, Rahman, Syed Asad, Hasnain, Seyed Ehtesham, Ehtesham, Nasreen Zafar
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 21.07.2020
• Subjects: Animals; Antibodies, Bacterial - immunology; Antigens, Bacterial - immunology; CD4+/CD8+ T cells; central memory; effector memory; Humans; Immunodominant Epitopes; Immunology; Macrophages - immunology; Mice; Mycobacterium smegmatis knock-in; Mycobacterium tuberculosis - immunology; TB subunit vaccine; Th1 Cells - immunology; Tuberculosis - immunology; Tuberculosis Vaccines - immunology; CD4+/CD8+ T cells; TB subunit vaccine; Mycobacterium smegmatis knock-in; effector memory; central memory

( ) persists as latent infection in nearly a quarter of the global population and remains the leading cause of death among infectious diseases. While BCG is the only vaccine for TB, its inability to provide complete protection makes it imperative to engineer BCG such that it expresses immunodominant...